優秀論文賞（旧論文賞） 過去の受賞者
2022年優秀論文賞（2023年選定）
Yukie Kuroda, Shinichiro Horiuchi, Satoha Aihoshi, Seiichi Ishida
Evaluation of Liver Fibrosis Induction and Inhibition using Human Cultured Hepatic Stellate Cell Spheroid
AATEX 27(2), 41-52, 2022
2021年優秀論文賞（2022年選定）
Riko Jinno,Yuji Komizu, Yurina Kado, Hideaki Ichihara, Yoko Matsumoto, Seiichi Ishida, Taku Matsushita
Evaluation for Inhibitory Effects of Hybrid Liposomes on the Growth of Breast Cancer Stem Cells using Soft Agar Colony Formation Assay
AATEX 26(1) ,1-8, 2021
2020年優秀論文賞（2021年選定）
Kosuke Inamura, Asuka Shiraki, Kazumi Inoue, Riko Jinno, Yuji Komizu, Tooru Takeda, Seiichi Ishida, and Taku Matsushita
Development of a New Culture Vessel using Hydrogen-rich Gelatin for Evaluation of Hydrogen Gas Effect on Cellular Toxicity
AATEX 25(2), 41-47, 2020.
2019年優秀論文賞（2020年選定）
Kevin Montagne, Katsuko S. Furukawa, and Takashi Ushida
Hydrostatic pressurization of dissociate ATDC5 aggregates as an in vitro model of mechanical load-induced chondrocyte damage.
AATEX 2019, Vol. 24, 2, 75-82
2018年優秀論文賞（2019年選定）
Ryutaro Miki, Yuki Kobayashi, Yuko Nakamura, Tomoko Asaka, Nahomi Imai, Yuka Hirayama, Osamu Hosoya, Yuya Egawa, and Toshinobu Seki
The development of a novel in vitro gastrointestinal absorption model comprising drug dissolution/migration/permeation processes: Interactions between a drug and an excipient.
AATEX 21(1): 1-13, 2016
2017年優秀論文賞（2018年選定）
Hiroshi Miyazaki, Kunihiko Yamashita, Tadashi Uchino, Toshiaki Takezawa, Hajime Kojima
Development of a Novel in Vitro Skin Sensitization Test Method using a Collagen Vitrigel Membrane Chamber.
AATEX 22(2): 141-154, 2017
2016年優秀論文賞（2017年選定）
Shinichiro Horiuchi, Yukie Kuroda, RyuyaFujii, Su-RyangKim, Seiichi Ishida
Deactivation of Hepatic Stellate Cells by Culturing on VECELL Inserts.
AATEX 23(2): 53-62, 2018
2015年優秀論文賞（2016年選定）
Shinya Koga, Anna Nakamura, Hideki Katayama, Katsuhiro Okumura, Kenji Yoshimura, Kiyotaka Shuzenji, Tetsuo Morinaga, Eiichi Hirano
Silicate fiber scaffold-based 3D perfusion cultures of the human colorectal cancer cell line HT-29 by using a microfluidic chip.
AATEX 20(2): 57-65, 2015
2013-2014年優秀論文賞（2015年選定）
Kokoro Iwasawa, Genya Tanaka, Takuya Aoyama, Mohammad Mahfuz Chowdhury, Kikuo Komori, Toshiko Tanaka-Kagawa, Hideto Jinno and Yasuyuki Sakai
Prediction of Phthalate Permeation Through Pulmonary Alveoli using a Cultured A549 Cell-based in Vitro Alveolus Model and a Numerical Simulation. AATEX
18(1):19-31, 2013
2012年優秀論文賞（2013年選定）
該当なし
2011年論文賞（2012年選定）
Tadashi Uchino1, Toshiaki Takezawa2, Yoshiaki Ikarashi1 and Tetsuji Nishimura1
1National Institute of Health Sciences, Tokyo, Japan, 2National Institute of Agrobiological Sciences, Ibaraki, Japan “Development of an Alternative Test for Skin Sensitization Using a Three-dimensional Human Skin Model Consisting of Dendritic Cells, Keratinocytes and Fibroblasts”
AATEX 16(1), 1-8, 2011
2010年論文賞（2011年度選定）
Kazuhiro Sato1, Tomohiro Umemura1, Taro Tamura1, Yukinori Kusaka1, Toshiko Ido2, Kohji Aoyama3, Atsushi Ueda5, Kohichi Harada4, Keiko Minamoto5, Takemi Otsuki5, Kunihiko Yamashita6, Tatsuya Takeshita7, Eiji Shibata8, Kunio Dobashi9, Satomi Kameo10, Muneyuki Miyagawa11, Masaaki Kaniwa12, Takahiko Yoshida13, Tetsuhito Fukushima14 and Kohtaro Yuta15*
1Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan, 2Department of Dermatology, School of Medicine, University of Fukui, Fukui, Japan, 3Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 4Department of Environmental Health, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, 5Department of Hygiene, Kawasaki Medical School, Okayama, Japan, 6Daicel Chemical Industries, Ltd., Hyogo, Japan, 7Department of Public Health, School of Medicine, Wakayama Medical University, Wakayama, Japan, 8Department of Hygiene, Aichi Medical University, Aichi, Japan, 9School of Health Sciences, Faculty of Medicine, Gunma University, Gunma, Japan, 10Department of Public Health, Gunma University, Gunma, Japan, 11National Institute of Occupational Safety and Health, Kanagawa, Japan, 12Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan, 13Department of Health Science, School of Medicine, Asahikawa Medical University, Asahikawa, Japan, 14Department of Hygiene and Preven-tive Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan, 15Fujitsu Limited, Tokyo, Japan (*present: In Silico Data Ltd., Chiba, Japan)
“A Respiratory Sensitization Study by a New Quantitative Structure-Activity Relationships (QSAR)” AATEX 15(3), 124-130, 2010
2009年論文賞（2010年選定）
Kazuhiro Sato1, Tomohiro Umemura1, Tarou Tamura1, Yukinori Kusaka1, Kohji Aoyama2, Atsushi Ueda3, Kohichi Harada3, Keiko Minamoto3, Takemi Otsuki4, Kunihiko Yamashita5, Tatsuya Takeshita6, Eiji Shibata7, Kunio Dobashi8, Satomi Kameo9, Muneyuki Miyagawa10, Masaaki Kaniwa11, Yoko Endo12, and Kohtaro Yuta13,14
1Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan, 2Department of Environmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 3Department of Environmental Health, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, 4Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, 5Daicel Chemical Industries, Ltd., Himeji, Japan, 6Department of Public Health, School of Medicine, Wakayama Medical University, Wakayama, Japan, 7Department of Hygiene, Aichi Medical University, Nagakute, Japan, 8School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Japan, 9Department of Public Health, Gunma University, Maebashi, Japan, 10National Institute of Occupational Safety and Health, Kawasaki, Japan, 11Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan, 12Research Center for Occupational Poisoning, Tokyo Rosai Hospital, Tokyo, Japan, 13Fujitsu Limited, Tokyo, Japan (14present: Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan
“Skin Sensitization Study by Quantitative Structure-Activity Relationships (QSAR)”
AATEX 14(3), 940-946, 2009
2008年論文賞（2009年選定）
Koichi Imai1, Shinji Kusakawa2, Akito Tanoue2, Makiko Kuwagata3, Mika Senuma3, Mami Furuya3 and Hiromasa Takashima3 1Department of Biomaterials, Osaka Dental University, Osaka, Japan, 2Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan, 3Laboratory of Toxicology, Hatano Research. Institute., FDSC, Kanagawa, Japan
“In Vitro Embryotoxicity Testing of Mercury Vapour by Differentiation of ES-D3 Cells”
AATEX 13(3), 118-122, 2008
2007論文賞（2008年選定）
Takashi Omori
Department of Biostatistics, Kyoto University, Japan
“A Measure Evaluating Relevance of a Validation Study of Alternatives to Animal Testing” AATEX 12(1), 25-31, 2006
Takashi Sozu1, Ayako Shiraishi2, Yohei Hyodo3, Chikuma Hamada3 and Isao Yoshimura3
1The Center for Advanced Medical Engineering and Informatics, Osaka University, Japan, 2Management and Biostatistics Department, Janssen Pharmaceutical K.K., Japan, 3Department of Management Science, Faculty of Engineering, Tokyo University of Science, Japan
“Interval Estimation of the 50% Effective Time in Small Sample Assay Data”
AATEX 12(2), 161-170, 2007
2005-2006年論文賞（2007年選定）
Yasuyuki Sakai1,2, Kengo Tomita2,3, Motoyuki Suzuki2,4, Yoshiro Ono5 and Akiyoshi Sakoda2 1 Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan, 2 Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan, 3 Current affiliation: Environmental Science Center, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 114-0033, Japan, 4 Current affiliation: United Nations University, 5-53-70 Jingu-mae, Shibuya-ku, Tokyo 150-8558, Japan, 5 Department of Environmental Engineering, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan
“Development of a Toxicity Evaluation System for Gaseous Compounds Using Air-liquid Interface Culture of a Human Bronchial Epithelial Cell Line, Calu-3”
AATEX 11(1), 59-67, 2005
2003-2004論文賞（2005年選定）
Masaaki Mori, Masatoshi Hoya, Mariko Sugiyama and Hiroshi Itagaki Safety & Analytical Research Center, Shiseido Co., Ltd., 2-12-1 Fukuura, Kanazawa-ku, Yokohama-ski, Kanagawa 236-8643, Japan
“Effects of Light Sources on the Prediction of Phototoxicity by the Yeast Growth Inhibition Phototoxicity Assay and the Red Blood Cell Photohemolysis Assay”
AATEX 10(1), 1-17, 2004
2002年論文賞（2003年選定）
Noriyuki Morikawa1, Katsuyasu Morota1, Shin-Ichiro Morita1, Hajime Kojima2, Satoru Nakata2 and Hiroaki Konishi2 1GUNZE Ltd., 2Nippon Menard Cosmetic Co., Ltd.
“Prediction of Human Skin Irritancy Using a Cultured Human Skin Model: Comparison of Chemical Application Procedures and Development of a Novel Chemical Application Procedure Using the Vitrolife-SkinTM Model”
AATEX 9(1), 1-10, 2002
黒澤努、大谷若菜
大阪大学医学部附属動物実験施設
“苦痛による生命科学実験分類”
AATEX 8(3-4), 113-121, 2002
2001年論文賞（2002年選定）
Tetsuya Watanabe1, Tetsuya Hasegawa1, Hidekazu Takahashi2, Takuya Ishibashi2, Kozo Takayama3 and Kenji Sugibayashi1 1Josai University, 2Toyobo Co., Ltd., 3Hoshi University
“Utility of the Three-dimensional Cultured Human Skin Model as a Tool to Evaluate Skin Permeation of Drugs”
AATEX 8(1), 1-14, 2001
2000年論文賞（2001年選定）
Hajime Kojima, Tomonori Katada and Hiroaki Konishi
Research Laboratories, Nippon Menard Cosmetic Co., Ltd.,2-7 Torimi-cho, Nishi-ku, Nagoya 451-0071, Japan
“Which Cytotoxicity Tests are Useful for Prediction of Skin Irritation by Surfactants?”
AATEX 6(2,3), 79-88, 2000
1998年論文賞（1999年選定）
Takashi Omori1, Kaoru Saijo2, Mayako Kato2, Hiroshi Itagaki3, Makoto Hayashi4, Satoru Miyazaki5, Tadao Ohno2, Hideaki Sugawara5, Noriko Teramoto2, Noriho Tanaka6, Shinobu Wakuri6 and Isao Yoshimura1
1Department of Management Science, Faculty of Engineering, Science University of Tokyo, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162, 2RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukaba Science City, Ibaraki 305, 3Shiseido Safety & Analytical Research Center,1050 Nippa-cho, Kohoku-Ku, Yokohama-shi 223,
4Division of Genetics and Mutagenesis, Mitamura Building, 26-1 Kaitaicho, Shinjuku-ku, Tokyo 112-0012 Japan 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, 5Life Science Research Information Laboratory, The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-01, 6Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano-shi, Kanagawa 257
“Validation Study on Five Cytotoxicity Assays by JSAAE — II. Statistical Analysis”
AATEX 5(1), 39-58, 1998
Hajime Kojima, Atsushi Sato, Asao Hanamura, Tomonori Katada and Hirokaki Konishi
Research Institute, Nippon Menard Cosmetic Co., Ltd., 2-7 Torimi-cho, Nishi-ku, Nagoya 451-0071 Japan
“Evaluation of Skin Irritation in a Reconstituted Human Dermal Model (3-D Model) Using Water Insoluble Fatty Acids, Fatty Alcohols and Hydrocarbons”
AATEX 5(4), 201-210, 1998
Tadao Ohno1, Masumi Asakura2, Takumi Awago3, Yoshihiro Futamura4, Akihiro Harihara5, Masato Hatao6, Chiharu Hattori7, Akira Hayasaka8, Makoto Hayashi9, Takashi Yahashi10, Zenzou Hirata4, Hiroshi Hori11, Hiroyoshi Hoshi12, Koichi Imai13, Ikuo Imazeki8, Takuya Ishibashi11, Hiroshi Itagaki6, Tatsuo Iwata14, Miyako Kakuma15, Shinya Kaneda16, Ikuo Kato5, Mayako Kato1, Tooru Kawahatsu17, Akio Kawakami18, akemi Kazama19, Akihiko Kido20, Shigemi Kimura21, Michiyo Kitazawa22, Shigefumi Kogiso23, Hajime Kojima24, Mayumi Kotani25, Masahiro Kuramochi21, Daijyo Maki26, Masako Matsuda27, Chihomi Mitsuoka26, Satoru Miyazaki28, Fumio Mizuno20, Minako Mori29, Katsunori Morimoto30, Matsuko Moriysu26, Keiya Nakajima29, Madoka Nakajima22, Masaaki Nakamura13, Masaki Nakamura4, Nahoko Nakano26, Shinobu Nakamura26, Akira Inegami31, Masato Nishino19, Tamotsu Nishitomi20, Kenji Ohkoshi32, Yuuko Okamoto32, Takashi Omori35, Hiroshi Ono34, Makoto Ono15, Yuko Osanai15, Kaoru Saijo1, Yuka Sano35, Kyoko Saotome36, Kazunori Sasaki5, Tetsuji Sasaki1, Hidetaka Sato37, Shinichiro Sato38, Hiroyasu Shimada7, Shoichiro Shimogo6, Kazuyuki Shimono16, Hiroshi Shionoya14, Hideaki Sugawara28, Yasuko Sugiki39, Shigeo Sugimoto40, Shigeru Sugimoto37, Junko Suzuki37, Kinya Takagaki4, Ken Takahashi41, Minoru Takizawa42, Chieko Tamaki23, Noriho Tanaka34, Jirou Taniya34, Noriko Teramoto1, Hisashi Torishima44, Toshiyuki Tsuchiya45, Motoo Uejima16, Hayao Ueno46, Yuji Ugai22, Shogo Wada47, Shinobu Wakuri34, Xinhai Wang1, Ikuo Watanabe29, Masami Watanabe48, Satoshi Yajima49, Yoshiki Yamagata19, Yuuzou Yamaguchi49, Osamu yamakita40, Ryohei Yamamoto44, Masanori Yoshida46, Isao Yoshimura33, Kouichi Yuhki43, Shiro Yukiyama40
1RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN), 3-1-1 Koyadai, Tsukaba Science City, Ibaraki 305, 2Japan Bioassay Laboratory, 2445 Hirasawa, Hadano-shi, Kanagawa 257, 3Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima-shi, 771-01, 4Toxicology Laboratory, Mochida Pharmaceutical Co., Ltd., 342 Gensuke, Fujieda-shi, Shizuoka 426, 5Shionogi Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka-shi, Osaka 561, 6Shiseido Safety & Analytical Research Center,1050 Nippa-cho, Kohoku-Ku, Yokohama-shi 223, 7Developmental Research Laboratory, Daiich Pharmaceutical Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134, 8Chugai Pharmaceutical Co., Ltd., 3-41-8 Takada, Toshima-ku, Tokyo 171, 9Division of Genetics and Mutagenesis, Mitamura Building, 26-1 Kaitaicho, Shinjuku-ku, Tokyo 112-0012 Japan 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, 10Ina Research Inc., 8047 Nishiminowa, Ina-shi, Nagano 399-45, 11Tsuruga Institute of Biotechnology, Toyobo Co., Ltd., 10-24 Toyo-cho, Tsuruga-shi, Futui 914, 12Research Institute for the Functional Peptides, 11-26 Minamisanban-cho, Yamagata-shi 990, 13Department of Biomaterials, Osaka Dental University, 1-5-31 Otemae, Chuo-ku, Osaka-shi 540, 14Department of Drug Safety Research, R & D Division, Eisai Co., Ltd., Takehaya, Kawashima-cho, Hashima-gun, Gifu 501-61, 15Beauty Care Products Laboratory, Nagase, Co., Ltd., 5-1 Kobuna-cho, Nihonbashi, Chuo-ku, Tokyo 103, 16Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc., 115 Kuguhara, Tateiwa, Muya-cho, Naruto-shi, Tokushima 772, 17Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama-shi 222, 18Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174, 19Biochemical Development & Production, Oriental Yeast Co., Ltd., 4-4-1 Minamisuita, Suita-shi, Osaka 564, 20Kashima Laboratory, Mitsubishi-kagaku Institute of Environmental and Toxicological Sciences, 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-02, 21BML Inc., 1361-1 Matoba, Kawagoe-shi, Saitama 350, 22Biosafety Research Center, Foods, Drugs and Pesticides, 582-2 Arahama, Shioshinden, Fukude-cho, lwata-gun, Shizuaka 437-12, 23Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 3-1-98 Kasugadanaka, Konohana-ku, Osaka-shi 554, 24Biochemical Research Institute, Nippon Menard Cosmetic Co., Ltd., 2-7 Torimi-cho, Nishi-ku, Nagoya-shi 451, 25R&D Planning HQ, Sunstar Inc., 3-1 Asahi-machi, Takatsuki-shi, Osaka 569, 26Panapharm Laboratories Co., Ltd. 1285 Kurisaki-cho, Uto-shi, Kumamoto 869-04, 27Research and Development Center, Duskin Co., Ltd., 4-19-8 Minamisuita, Suita-shi, Osaka 564, 28Life Science Research Information Laboratory, The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-01, 29The Center of Japan Biological Chemistry, 52 Fukue, Kaizu-cho, Kaizu-gun, Gifu 503-06, 30Takara Belmont Co., Ltd., 5-1 Takamatsu, Kouzai-cho, Koga-gun, Shiga 520-32, 31Deparment of Obstetrics and Gynecology, Fukui Medical School, 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Futui 910-11, 32Division of Fundamental Research, KOSE Co., 1-18-4 Azusawa, Itabashi-ku, Tokyo 174, 33Department of Management Science, Faculty of Engineering, Science University of Tokyo, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162, 34Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano-shi, Kanagawa 257, 35Biotechnology Research Laboratories, TAKARA SHUZO Co., Ltd., 3-4-1 Seta, Ohtsu-shi, Shiga 520-21, 36Yokohama City Institute of Health, 1-2-17 Takigashira, Isogo-ku, Yokohama-shi 235, 37Japan Food Research Laboratories, 6-11-1O Nagayama, Tama-shi, Tokyo 206, 38Division of Radiation Medicine, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-shi 263, 39Menicon Co., Ltd., 5-1-10 Takamoridai, Kasugai-shi, Aichi 487, 40Drug Safety Laboratory, Taiho Pharmaceutical Co., Ltd., 224-2 Ebisuno, Hiraishi, Kawauchi-Cho, Tokushima-shi 771-01, 41The Institute of Environmental Toxicology, 4321 Uchimoriya-cho, Mitsukaido-shi, Ibaraki 303, 42Hakko Electric Machine Works Co. Ltd., 3055 Togura, Toguramachi, Hanishina-gun, Nagano 389-08, 43Koken Bioscience Institute, Koken Co., Ltd., 2-11-12 Nakane, Meguro-ku, Tokyo 152, 44Kurabo Industries Ltd., 14-41 Shimokida-cho, Neyagawa-shi, Osaka 572, 45Safety Evaluation Center, Central Research Laboratory, Showa Denko K K, 1-1-1 Ohnodai, Midori-ku, Chiba-shi 267, 46Takeda Analytical Research Laboratories, Ltd., 2-17-85 Juso-honmachi, Yodogawa-ku, Osaka 532, 47Wako Pure Chemical Industries, Ltd., 6-1 Takadacho, Amagasaki-shi, Hyogo 661, 48Division of Radiation Biology, Department of Health Science, Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi 852, 49Central Research Laboratory, Takasago International Co., 1-4-11 Nishiyawata, Hiratsuka-shi, Kanagawa 254, Japan
“Validation Study on Five Cytotoxicity Assays by JSSSE — I. Overview of The Study And Analyses of Variations of ED50 Values” AATEX 5(1), 1-38, 1998